Malaria is widespread, especially in the rural areas and travellers are advised to avoid mosquito bites and use mosquito repellents and chemical prophylaxis. Yellow fever vaccination is required for entry into the country. Hepatitis A & B, cholera and typhoid fever inoculation is also recommended.

Risk of meningitis is high in the northern region of Ghana. It is advisable to take a vaccine for Meningitis types A, C, Y and W135. Swimming in freshwater rivers and lakes is not advisable.

Although the AIDS/HIV rate is lower than other sub-Saharan African countries, visitors must maintain extreme caution. Avoid getting a tattoo done as the needles could be contaminated. Receiving a blood transfusion while in Ghana greatly increases your risk of acquiring HIV.