Panama on an average is considered very safe for tourists. There are only a few places where caution has to be practised. All spots in the city of Colon in general are considered dangerous, and it is best to avoid a visit to the city if not very urgent. Outskirts of Panama City, for instance El Chorrillo, Curundu and El Marañón are also not safe for tourist as there have been various incidents of serious crimes in these areas. Tourists are expected to be careful while travelling alone at night and should avoid deserted streets and roads.

Except for Bocas Del Toro, all other places have provision for safe drinking water. There is availability of excellent healthcare services in most parts of the country.

Dengue fever and malaria are a concern for the foreigners who should be careful against mosquito bite and carry a mosquito repellent at all times. Immunisation against yellow fever, hepatitis and Hantavirus is recommended prior to a visit to Panama.